Does your PCR instrument suffer from broken solder joints or performance degradation in thermoelectric coolers (TECs) due to frequent thermal cycling (50-95°C)? Have you experienced declining temperature uniformity after prolonged operation, compromising test accuracy? Are rising maintenance costs troubling you due to insufficient TEC cycle life?
P&N's innovative flexible soldering layer TEC technology is specifically engineered for PCR's demanding conditions. It significantly enhances TEC reliability and lifespan under thermal shock, empowering your equipment with more stable and durable temperature control performance.
Polymerase Chain Reaction (PCR) nucleic acid testing instruments require rapid and repeated thermal cycling (typically 20-40 cycles), with each cycle involving high-temperature (95°C), low-temperature (50-65°C), and moderate-temperature (72°C) stages to achieve efficient DNA amplification. This process demands extremely precise and stable temperature control, presenting several key challenges:
Severe Thermal Shock: Conventional thermoelectric coolers (TECs) experience mechanical stress due to rapid heating and cooling (6-9°C/sec), leading to solder joint fatigue and reduced lifespan.
Stringent Temperature Uniformity: PCR sample trays must maintain a temperature gradient within ±0.5°C. However, long-term ACR (module resistance) drift or ceramic substrate deformation can cause temperature deviations, particularly in edge wells.
Reliability Limitations: Standard TECs can only endure ~100,000 thermal cycles (e.g., 50°C↔95°C), falling short of the longevity requirements for high-throughput PCR systems.
To address these challenges, we have developed the next-generation TCR Series TEC with a flexible solder-layer design, leveraging material and structural innovations to significantly improve PCR instrument performance:
Stress-Absorbing Structure: A thermally conductive flexible layer beneath the cold-side ceramic substrate mitigates contraction/expansion stress, reducing shear fatigue in semiconductor solder joints and extending operational life.
High Precision & Durability: Optimized thermoelectric materials and advanced packaging enable the TCR Series to withstand over 500, 000 cycles (5× more than conventional TECs) in extreme 50°C↔95°C thermal shock tests, ensuring long-term PCR system stability.
Narrow-Zone Temperature Control: Customizable elongated TEC designs minimize thermal gradients across PCR trays, enabling precise melting temperature optimization for enhanced detection accuracy.
Application Value: The TCR Series delivers faster ramp rates, lower temperature fluctuations, and extended service life for real-time PCR systems, supporting high-efficiency, high-precision, and low-maintenance nucleic acid testing.
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